Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | strong expression in keratinocytes located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions | Homo sapiens | - |
additional information | KLK6 is not detectable in tumor cells of primary and metastatic melanoma and is specifically absent in atypic melanocytes of dysplastic nevi | Homo sapiens | - |
stromal cell | strong expression in stromal cells located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
kallikrein-related peptidase 6 | - |
Homo sapiens |
KLK6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | recombinant Klk6 protein significantly induces melanoma cell migration and invasion accompanied by an accelerated intracellular Ca2+ flux. KLK6-induced intracellular Ca2+ flux and tumor cell invasion critically depends on the protease-activated receptor 1 | Homo sapiens |